Tumor-Educated Platelets Facilitate Thrombus Formation Through Migration

Tumor-Educated Platelets Facilitate Thrombus Formation Through Migration

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Platelets are small anucleate cells that circulate in the blood and form thrombi.Tumor-educated platelets are the platelets derived from cancer patients.Although many have reported that tumor-educated platelets are associated with cancer-associated thrombosis, their function in this process is poorly understood.Here we first collect the clinical data from 100 different cancer patients, click here showing that cancer patients are in a hypercoagulable state.

Our experiment shows that tumor-educated platelets from melanoma-burdened mouse models can migrate faster and longer, forming more clots (thrombus).However, the plasma from tumor mice can inhibit platelet migration.The RNA citronella horse shampoo sequence profile of tumor-educated platelets shows that many genes associated with cell migration and cell skeleton expressed significantly higher.Our research offers a new insight into the tumor-educated platelets to better understand the thrombus formation.